/* Shared FDA-style knowledge archive for ALL REG sites. */
.allreg-knowledge-archive{font-family:Inter,"Noto Sans SC","Microsoft YaHei",sans-serif;color:#15243b}.allreg-knowledge-archive *{box-sizing:border-box}.allreg-knowledge-archive .shell{width:min(1188px,calc(100% - 48px));margin-inline:auto}.allreg-knowledge-archive a{text-decoration:none}.allreg-knowledge-archive .kicker{color:#215ee8;font-size:11px;font-weight:750;letter-spacing:.12em}
.archive-hero{padding:48px 0 32px;border-bottom:1px solid #e5ebf4;background:#f7f9fd}.archive-hero h1{margin:12px 0 14px;font-size:clamp(32px,4vw,44px);line-height:1.25;color:#13223f;letter-spacing:-.035em}.archive-hero p{max-width:820px;margin:0;color:#60718a;font-size:15px;line-height:1.95}.archive-section{padding-top:32px;padding-bottom:72px}.archive-layout{display:grid;grid-template-columns:minmax(0,1fr) 250px;gap:38px;align-items:start}.archive-main{min-width:0}.archive-tools{padding-bottom:26px;border-bottom:1px solid #dfe7f2}.archive-search-label{display:block;margin-bottom:8px;font-size:13px;font-weight:700;color:#243754}.archive-search-box{display:flex;align-items:center;gap:12px;background:#fff;border:1px solid #d7e1f0;border-radius:10px;padding:0 15px}.archive-search-box>span{font-size:28px;line-height:1;color:#7286a5}.archive-search-box input{width:100%;min-width:0;border:0;outline:0;padding:14px 0;background:transparent;font:inherit;font-size:14px;color:#142641}.archive-search-box:focus-within{outline:2px solid #2563eb;outline-offset:2px}.archive-search-box input::placeholder{color:#8692a5}.archive-filters{display:flex;flex-wrap:wrap;gap:8px;margin-top:18px}.archive-filters button{border:1px solid transparent;border-radius:6px;padding:7px 12px;background:#edf2f9;color:#50617c;font-size:13px;line-height:1.5}.archive-filters button[aria-pressed=true]{background:#215ee8;color:#fff}.archive-filters button:hover{border-color:#9ab7f1}.archive-filters button:focus-visible,.archive-more:focus-visible,.archive-entry a:focus-visible,.archive-sidebar a:focus-visible{outline:2px solid #2563eb;outline-offset:4px}.archive-list-heading{display:flex;flex-wrap:wrap;align-items:baseline;justify-content:space-between;gap:8px;margin:25px 0 18px}.archive-list-heading h2{margin:0;font-size:20px;color:#192b48}.archive-list-heading p{margin:0;font-size:12px;color:#7b889d}.archive-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}.archive-entry{display:flex;flex-direction:column;padding:23px;background:#fff;border:1px solid #e0e7f1;border-radius:10px;min-width:0;transition:border-color .15s}.archive-entry:hover{border-color:#a4bce7}.archive-entry[hidden],.archive-empty[hidden],.archive-more[hidden]{display:none!important}.archive-entry-meta{display:flex;flex-wrap:wrap;align-items:center;gap:7px 12px;font-size:11px;color:#7a879a;line-height:1.6}.archive-category{font-size:11px;color:#1b5fdc;font-weight:600}.archive-entry h3{margin:15px 0 10px;font-size:19px;line-height:1.6;font-weight:700;color:#172a49;overflow-wrap:anywhere}.archive-entry h3 a:hover{color:#1d60df}.archive-entry>p{margin:0 0 20px;color:#63738a;font-size:14px;line-height:1.95}.archive-read{display:flex;justify-content:space-between;align-items:center;margin-top:auto;padding-top:14px;border-top:1px solid #edf0f6;font-size:12px;font-weight:600;color:#1e5ed8}.archive-read span{font-size:18px}.archive-updates .archive-grid{grid-template-columns:1fr;gap:0}.archive-updates .archive-entry{border-width:0 0 1px;border-radius:0;padding:24px 4px;background:transparent}.archive-updates .archive-entry:first-child{padding-top:5px}.archive-updates .archive-entry h3{margin-top:10px;font-size:21px}.archive-updates .archive-entry>p{margin-bottom:12px}.archive-updates .archive-read{border:0;padding-top:0;justify-content:flex-start;gap:12px}.archive-cases .archive-entry{border-top:3px solid #2b5fba}.archive-empty{text-align:center;padding:45px 20px;border:1px dashed #cdd9e9;border-radius:10px;color:#687b95}.archive-empty h3{color:#223956;margin:0 0 10px}.archive-more{display:block;margin:28px auto 0;border:1px solid #cddbf0;border-radius:8px;padding:11px 24px;background:#fff;color:#225dcc;font-size:13px;font-weight:600}.archive-more span{margin-left:15px}.archive-side-block{padding:23px 20px;background:#f4f7fc;border:1px solid #e2e9f3;border-radius:10px}.archive-sidebar h2{margin:0 0 16px;font-size:16px;color:#233653}.archive-side-link{display:flex;align-items:center;justify-content:space-between;gap:12px;padding:12px 0;border-top:1px solid #e0e7f1;font-size:13px;color:#5c6e89;line-height:1.5}.archive-side-link.current{color:#1f60de;font-weight:700}.archive-side-link:hover{color:#1859d5}.archive-side-link>span{font-size:11px;color:#8291a8}.archive-side-note{padding:25px 4px}.archive-side-note .kicker{font-size:9px;letter-spacing:.12em}.archive-side-note h2{margin:10px 0}.archive-side-note p{margin:0 0 12px;font-size:13px;line-height:1.95;color:#687a94}.archive-side-note>a{font-size:12px;font-weight:600;color:#215ee0}.archive-other-sections{display:flex;flex-direction:column;border-top:1px solid #dfe6f0}.archive-other-sections a{display:flex;justify-content:space-between;padding:13px 4px;color:#42648f;font-size:13px;border-bottom:1px solid #e6ebf3}
@media(max-width:1000px){.archive-layout{grid-template-columns:minmax(0,1fr) 220px;gap:24px}.archive-grid{grid-template-columns:1fr}}
@media(max-width:680px){.archive-hero{padding:30px 0 24px}.archive-hero h1{font-size:32px}.archive-hero p{font-size:14px;line-height:1.9}.archive-section{padding-top:22px;padding-bottom:42px}.archive-layout{grid-template-columns:1fr;gap:32px}.archive-entry{padding:20px}.archive-entry h3,.archive-updates .archive-entry h3{font-size:18px}.archive-entry>p{font-size:14px}.archive-filters{gap:7px}.archive-filters button{font-size:12px;padding:7px 10px}.archive-search-box input{font-size:13px;padding:13px 0}.archive-list-heading h2{font-size:19px}.archive-sidebar{display:grid;grid-template-columns:1fr 1fr;gap:18px}.archive-side-block{padding:18px 15px}.archive-side-note{padding:10px 0}.archive-other-sections{grid-column:1/-1}.archive-entry-meta{font-size:11px}}
@media(max-width:380px){.archive-sidebar{grid-template-columns:1fr}.archive-other-sections{grid-column:auto}}
/* FDA knowledge archive: editorial guidance with restrained interaction. */
.knowledge-hero{padding-block:43px 45px;background:#f7f9fd}
.knowledge-hero .knowledge-hero-grid{display:grid;grid-template-columns:minmax(0,1fr) minmax(310px,390px);gap:clamp(34px,5vw,76px);align-items:center}
.knowledge-hero-copy{max-width:660px}
.knowledge-hero .knowledge-hero-copy h1{font-size:clamp(35px,3.7vw,48px);margin:12px 0 14px}
.knowledge-hero .knowledge-hero-copy>p{max-width:650px;font-size:15px;line-height:1.9}
.knowledge-hero-starter{padding:23px 25px 19px;border:1px solid #dae5f3;border-radius:13px;background:#fff;box-shadow:0 12px 34px rgba(29,57,101,.045)}
.knowledge-hero-starter .kicker{font-size:10px}
.knowledge-hero-starter h2{margin:7px 0 17px;color:#172b4b;font-size:19px;line-height:1.5}
.knowledge-starter-links{border-top:1px solid #e8edf5}
.knowledge-starter-links a{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:4px 10px;align-items:center;padding:12px 3px;border-bottom:1px solid #e8edf5;color:#172b4b;text-decoration:none}
.knowledge-starter-links a span{grid-column:1;color:#6b82a4;font-size:10px;font-weight:700;letter-spacing:.05em}
.knowledge-starter-links a strong{grid-column:1;font-size:13px;line-height:1.5;font-weight:650}
.knowledge-starter-links a b{grid-column:2;grid-row:1/3;color:#2864dc;font-size:17px;font-weight:500}
.knowledge-starter-links a:hover,.knowledge-starter-links a:focus-visible{color:#1f5dd3;background:#f5f8fe}
.knowledge-starter-links a:focus-visible{outline:2px solid #2563eb;outline-offset:2px}
.knowledge-hero-starter>p{margin:13px 0 0;color:#78879c;font-size:11px;line-height:1.7}
.archive-knowledge .archive-entry{border-color:#dce6f3;box-shadow:0 4px 14px rgba(25,50,91,.025)}
.archive-knowledge .archive-entry:hover,.archive-knowledge .archive-entry:focus-within{border-color:#acc3ea;box-shadow:0 13px 27px rgba(25,58,113,.075)}
.archive-knowledge .archive-entry h3{line-height:1.5}
.archive-knowledge .archive-read span{display:inline-block;transition:transform .2s ease}
.archive-knowledge .archive-entry:hover .archive-read span,.archive-knowledge .archive-entry:focus-within .archive-read span{transform:translateX(4px)}
.archive-knowledge .archive-filters button{transition:background-color .18s,border-color .18s,color .18s}
@media(prefers-reduced-motion:no-preference){.knowledge-starter-links a,.archive-knowledge .archive-entry{transition:transform .2s,border-color .2s,box-shadow .2s,background-color .2s}.knowledge-starter-links a:hover,.knowledge-starter-links a:focus-visible{transform:translateX(3px)}.archive-knowledge .archive-entry:hover,.archive-knowledge .archive-entry:focus-within{transform:translateY(-2px)}}
@media(prefers-reduced-motion:reduce){.archive-knowledge .archive-read span,.archive-knowledge .archive-filters button{transition:none}}
@media(max-width:900px){.knowledge-hero .knowledge-hero-grid{grid-template-columns:1fr;gap:26px}.knowledge-hero-starter{max-width:680px}.knowledge-hero{padding-block:35px}}
@media(max-width:680px){.knowledge-hero{padding-block:28px 30px}.knowledge-hero .knowledge-hero-copy h1{font-size:32px}.knowledge-hero .knowledge-hero-copy>p{font-size:14px}.knowledge-hero-starter{padding:20px}.knowledge-hero-starter h2{font-size:18px}.knowledge-starter-links a{padding-block:11px}}

.allreg-knowledge-archive .archive-sidebar{position:sticky;top:100px;max-height:calc(100dvh - 120px);overflow:auto}.allreg-knowledge-archive .archive-side-link{width:100%;border-right:0;border-bottom:0;border-left:0;background:transparent;text-align:left;font:inherit;cursor:pointer}.allreg-knowledge-archive .archive-read{color:#1e5ed8}.allreg-knowledge-archive .archive-hero p{color:#60718a}@media(max-width:680px){.allreg-knowledge-archive .shell{width:min(100% - 32px,1188px)}.allreg-knowledge-archive .archive-sidebar{position:static;max-height:none;overflow:visible}}